Question 1

What is the SOOTHE Trial, and why is it important?

Accepted Answer

The SOOTHE Trial is a clinical trial that investigates if pregnenolone, a neuroactive steroid, can improve brain health and depressed mood in people with HIV, without causing too many side effects.

Study participants have an opportunity to contribute to scientists' knowledge about new treatments for depression in those living with HIV.

Question 2

Where is SOOTHE being conducted?

Accepted Answer

The trial takes place at MGH Main Campus and MGH Charlestown Navy Yard in Boston, MA. Participants travel to those locations for 4 in-person visits. We will provide local travel reimbursement and free on-site parking.

• MGH Main Campus: 55 Fruit St, Cox Building, Floor 6, Boston, MA 02114
 • MGH Charlestown Navy Yard: 149 13th Street, Martinos Center, Floor 1, Charlestown, MA 02129

Question 3

How many people are participating in the SOOTHE trial?

Accepted Answer

We hope to enroll 120 adults with HIV.

Question 4

What happens during check-in calls?

Accepted Answer

Study staff will schedule 15-minute phone calls with participants between visits. During this time, we will ask about their mood and any side effects they may be experiencing.

Question 5

What will happen during each visit?

Accepted Answer

It varies for each visit.

Generally, participants complete questionnaires about how they are feeling, complete a brief physical exam with the study doctor, and get their blood drawn. The second and the fourth (final) visit will be longer than others due to a 2-hour MRI brain scan.

Question 6

How long does it take to finish the SOOTHE trial?

Accepted Answer

It takes about 2-3 months to complete the trial.

Question 7

Are participants compensated for time and travel?

Accepted Answer

Yes. We provide compensation for time and participation at the end of each visit. Participants receive up to $609 at the completion of the study. We also offer travel reimbursement, free parking at MGH, and meal vouchers.

Question 8

Who funds the SOOTHE trial?

Accepted Answer

SOOTHE is funded by the National Institute of Health (NIH), more specifically the National Institute of Mental Health (NIMH) which is one of the centers that make up the NIH.

Welcome to the SOOTHE Trial

Frequently Asked Questions (FAQ)

Thank you for supporting SOOTHE! 🙏