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About the SOOTHE Trial

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Brain health is important!

Caring for your brain health and mood is just as important as caring for your physical health. Healthy brain and mood are essential to living a happy, healthy, and productive life, but they can be especially challenging for people with HIV. We are committed to improving the lives of people with HIV through brain health research.

Why SOOTHE trial matters

Depression or low mood can be severe and may negatively impact relationships, work, and quality of life. People with HIV are at increased risk and have specific risk factors for low mood that current antidepressant drugs may not affect. We believe that our study medication "pregnenolone" may be able to improve these risk factors and want to study if it can help you live a happier, healthier, and more productive life.

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